Potential of ionic liquids as emerging green solvent for the pretreatment of lignocellulosic biomass.

Lignocellulosic biomass is available in abundance as a renewable resource, but the major portion of it is often discarded as waste without utilizing its immense potential as an alternative renewable energy resource. To overcome recalcitrance of lignocellulosic biomass, various pretreatment methods are applied to it, so that the complex and rigid polymeric structure can be broken down into fractions susceptible for enzymatic hydrolysis. Effective and efficient biomass processing is the goal of pretreatment methods, but none of the explored pretreatment methods are versatile enough to fulfil the requirement of biomass processing with greater flexibility in terms of operational cost and desired output efficiency. Deployment of green solvents such as ionic liquids for the pretreatment of lignocellulosic biomass has been a topic of discussion amongst the scientific community in recent times. The presented work provides a detailed overview on the deployment of ionic liquid for the pretreatment of lignocellulosic biomass coupled with a brief discussion on other pretreatments methods. The recyclability and reusability along with other unique properties makes an ionic liquid pretreatment different from the other traditional pretreatment methods. Also, this study explores diverse critical parameters that governs the dissolution process of biomass. Hazardous properties of ionic liquids have also been explored. Future perspective and recommendations have been given for an efficient, effective, and eco-friendly deployment of ionic liquid in biomass pretreatment process.

Advances in phase change materials and nanomaterials for applications in thermal energy storage.

Phase-changing materials are nowadays getting global attention on account of their ability to store excess energy. Solar thermal energy can be stored in phase changing material (PCM) in the forms of latent and sensible heat. The stored energy can be suitably utilized for other applications such as space heating and cooling, water heating, and further industrial processing where low-temperature heat energy is required. The presented work attempts to evaluate past, present, and future trends in the development of energy storage materials and their encapsulation techniques for efficient utilization of the available energy. Hybrid PCM with nanoparticles has excellent potential to tailor thermo-physical properties and uplift the efficiency of energy storage systems. Synergistic use of PCM with nanomicromaterial can further improve the capacity of energy storage system along with the charging and discharging efficiencies of the system. Impacts of the size of particle, concentration ratio, and shape of particle have been studied to assess their effectiveness in enhancing storage efficiency of the systems. Waste heat recovered and stored in energy storage materials can undoubtedly improve the total energy availability of the source, thus enhancing the exergy efficiency with simultaneous reduction in the entropy generation rate. Core-shell nanoparticles can further improve the optical absorptance spectra towards an infrared region of thermal energy. Paraffin wax-based NEPCMs with graphene nanoplatelets achieve 2.14 W/(m·K) thermal conductivity, enabling faster and more efficient heat transmission and lowering charging and discharging times for thermal storage devices.

An experimental investigation on the effects of magnesia and alumina nano additives on the exhaust emissions and performance of CI engine using spirulina microalgae biodiesel.

The need for non-renewable fuels is steadily decreasing with their ever-increasing cost and air pollution. As a result, renewable fuel such as biofuel is used as a fuel substitute for diesel engines. The effects of magnesia and alumina nanoparticles on the exhaust pollutants and performance of a naturally aspirated, 17.5 compression ratio, 4-stroke CI engine operating on spirulina microalgae biodiesel, and its amalgams were explored. Oxides of nitrogen, thermal efficiency, carbon dioxide, fuel consumption, and hydrocarbons were among the attributes studied. Test outcomes revealed that the doping of magnesia and alumina nano additives in spirulina biodiesel resulted in increased thermal efficiency and oxides of nitrogen, succeeded by a decrease in fuel consumption and hydrocarbons, at all loads, compared to amalgams without nano additives. At maximum load, the increase in thermal efficiency and oxides of nitrogen was found to be 1.15 and 1.46% with nano magnesia-doped blends when compared to corresponding spirulina blends. On the other, hand when nano alumina is doped in spirulina amalgams, the increase in thermal efficiency and oxides of nitrogen was observed to be 0.82 and 0.97%, respectively. Similarly, fuel consumption and hydrocarbons were reduced by 1.02 and 9.52%, 1.014, and 7.66%%, respectively, for magnesia and alumina-enriched biodiesel, contrasted to that of biodiesel blends.

Resistance to unfolding by acidic pH and resistance to lysosomal degradation explains disease-association of HLA-B27 subtypes.

Several hypotheses have been proposed to explain the high rate of disease association of HLA-B27 with ankylosing spondylitis (AS), including formation of disulfide-bonded dimers and misfolding of the heavy chain (HC), involving formation of high molecular weight (HMW) multimers. Recently, we have shown that the HMW entities of non-disease associated (non-DA) subtypes cause activation of endosomal-lysosomal pathways, while disease-associated (DA) subtypes of HLA-B27 cause activation of autophagy and unfolded protein response (UPR) pathways. In this paper, we seek an explanation for the failure of these pathways to degrade the HMW entities of DA subtypes of HLA-B27, using a combination of in vitro assays, using extracellular domains of heavy chains (EDHC), as well as in vivo assays, using stable transfectants of the full lengths of heavy chains (FLHC) of DA and non-DA subtypes. Our data shows that both DA and non-DA subtypes form HMW entities. However, non-DA HMW entities display far greater levels of degradation than DA HMW species. Non-DA EDHC display greater loss of structure at lysosomal pH in vitro. This was confirmed by experiments showing that (i) DA FLHCs co-localize with LAMP1, and (ii) induction of autophagy by rapamycin causes significant decrease in levels of non-DA HMW entities, but not that of DA HMW entities. These results point towards lack of facile lysosomal clearance of FLHCs of DA subtypes, suggesting that disease association of HLA-B27 subtypes is correlated with higher persistence of HMW entities in the low pH of lysosomes, with higher potential to trigger immune response.

Advancements in solar technologies for sustainable development of agricultural sector in India: a comprehensive review on challenges and opportunities.

Agriculture is the main occupation of the majority of people in India. The majority of the population in India is dependent (directly or indirectly) on agriculture as an occupation. The agriculture sector requires more freshwater and power for better yield in the current scenario. Nevertheless, the ever-increasing rate of energy consumption, limited fossil fuels, and rising pollution have made the expansion of renewable resources essential. Due to the suitable solar potential available in India, the deployment of solar energy has been more as compared to other renewable resources. The current study aims to discuss the various technologies, initiatives and policies of solar energy usage in agriculture. This work delivers an assessment of the advancement of solar energy vis-à-vis agricultural applications through the greenhouse concept and photovoltaic approach in India. Various agricultural applications of solar energy, such as solar water desalination system, solar water pumping system, solar crop dryer system for food safety, etc. are discussed as a means to promote solar-based technology. It also highlights the scenario of solar energy in India with important accomplishments, developmental approaches, and future potential. In-depth studies of various policies and government initiatives including those in research and development are also discussed. The current survey on solar technologies will be an aid to agribusiness frameworks to comprehend the statuses, obstructions, and extent of advancement. Finally, some future recommendations for further developments in this approach are discussed. This work sheds light on varied areas of solar energy-assisted agricultural systems as a potentially sustainable and eco-friendly pathway.

Differences in Cellular Clearing Mechanisms of Aggregates of Two Subtypes of HLA-B27.

Ankylosing spondylitis (AS) belongs to a group of diseases, called spondyloarthropathies (SpA), that are strongly associated with the genetic marker HLA-B27. AS is characterized by inflammation of joints and primarily affects the spine. Over 160 subtypes of HLA-B27 are known, owing to high polymorphism. Some are strongly associated with disease (e.g., B*2704), whereas others are not (e.g., B*2709). Misfolding of HLA-B27 molecules [as dimers, or as high-molecular-weight (HMW) oligomers] is one of several hypotheses proposed to explain the link between HLA-B27 and AS. Our group has previously established the existence of HMW species of HLA-B27 in AS patients. Still, very little is known about the mechanisms underlying differences in pathogenic outcomes of different HLA-B27 subtypes. We conducted a proteomics-based evaluation of the differential disease association of HLA B*2704 and B*2709, using stable transfectants of genes encoding the two proteins. A clear difference was observed in protein clearance mechanisms: whereas unfolded protein response (UPR), autophagy, and aggresomes were involved in the degradation of B*2704, the endosome-lysosome machinery was primarily involved in B*2709 degradation. These differences offer insights into the differential disease association of B*2704 and B*2709.